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| Possible Ranking | Organization/by individual | Country / region | Headquarters | Endowment (USD) | Founded / donations |
| 1 | Novo Nordisk Foundation | Denmark | Copenhagen | $49.1 billion | 1989 |
| 2 | Bill & Melinda Gates Foundation | United States | Seattle | $46.8 billion | 1994 |
| 3 | Stichting INGKA Foundation | Netherlands | Leiden | $36 billion | 1982 |
| 4 | Wellcome Trust | United Kingdom | London | $32.9 billion | 1936 |
| 5-6 | Howard Hughes Medical Institute | United States | Chevy Chase, Maryland | $23.8 billion | 1953 |
| 7-8 | Azim Premji Foundation | India | Bangalore | $21.0 billion | 2001 |
| 9 | Garfield Weston Foundation | United Kingdom | London | $15.7 billion | 1958 |
| 10 | Lilly Endowment | United States | Indianapolis | $15.1 billion | 1937 |
| 11 | Ford Foundation | United States | New York City | $13.7 billion | 1936 |
| 12 | Silicon Valley Community Foundation | United States | San Jose, California | $13.6 billion | 2007 |
| 13 | Kamehameha Schools | United States | Honolulu | $11.5 billion | 1887 |
| 14 | Robert Wood Johnson Foundation | United States | Princeton, New Jersey | $11.4 billion | 1972 |
| 15 | J. Paul Getty Trust | United States | Los Angeles | $10.4 billion | 1982 |
| 16 | Mohammed bin Rashid Al Maktoum Foundation | United Arab Emirates | Dubai | $10.08 billion | 2007 |
| 17 | William and Flora Hewlett Foundation | United States | Menlo Park, California | $8.74 billion | 1967 |
| 18 | Li Ka Shing Foundation | Hong Kong | Hong Kong | $8.3 billion | 1980 |
| 19 | W. K. Kellogg Foundation Trust | United States | Battle Creek, Michigan | $8.2 billion | 1930 |
| 20 | The Church Commissioners for England | United Kingdom | London | $7.5 billion | 1948 |
| 21 | The Mastercard Foundation | Canada | Toronto | $7.1 billion | 2006 |
| 22 | The Else Kröner- Fresenius Foundation | Germany | Bad Homburg | $7 billion | 1983 |
| 23 | Children’s Investment Fund Foundation | United Kingdom | London | $6.6 billion | 2002 |
| 24 | Gordon and Betty Moore Foundation | United States | Palo Alto, California | $6.4 billion | 2000 |
| 25 | David and Lucile Packard Foundation | United States | Los Altos, California | $6.3 billion | 1964 |
| 26 | Andrew W. Mellon Foundation | United States | New York City | $6.18 billion | 1969 |
| 27 | John D. and Catherine T. MacArthur Foundation | United States | Chicago | $6.0 billion | 1975 |
| 28 | Robert Bosch Foundation | Germany | Stuttgart | $6 billion | 1964 |
| 29 | Conrad N. Hilton Foundation | United States | Westlake Village, California | $5.89 billion | 1944 |
| 30 | The Leona M. and Harry B. Helmsley Charitable Trust | United States | New York City | $5.54 billion | 1999 |
| 31 | Nemours Foundation | United States | Jackson, Florida | $4.6 billion | 1936 |
| 32 | Bloomberg Philanthropies | United States | New York City | $4.24 billion | 2004 |
| 33 | The Volkswagen Foundation | Germany | Hannover | $3.93 billion | 1961 |
| 34 | Tulsa Community Foundation | United States | Tulsa, Oklahoma | $3.8 billion | 1998 |
| 35 | Rockefeller Foundation | United States | New York City | $3.7 billion | 1913 |
| 36 | The Kresge Foundation | United States | Troy, Michigan | $3.6 billion | 1924 |
| 37 | Knut and Alice Wallenberg Foundation | Sweden | Stockholm | $3.60 billion | 1917 |
| 38 | California Health Care Foundation | United States | Los Angeles | $3.56 billion | 1996 |
| 39 | The Duke Endowment | United States | Charlotte, NC | $3.37 billion | 1924 |
| 40 | Calouste Gulbenkian Foundation | Portugal | Lisbon | $3.2 billion | 1956 |
| 41 | Realdania | Denmark | Copenhagen | $2.9 billion | 2000 |
| 42 | Greater Kansas City Community Foundation | United States | Kansas City, Missouri | $2.7 billion | 1978 |
| 43 | Simons Foundation | United States | New York City | $2.6 billion | 1994 |